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Postdoctoral Researcher in 'Organic Chemistry and Chemical Biology' (f/m/d)
Helmholtz-Zentrum f眉r Infektionsforschung GmbH (HZI)
Fighting pathogens
together!
Postdoctoral Researcher in 鈥極rganic Chemistry and Chemical Biology鈥� (f/m/d)
Job advertisement no.: 064/2025
Starting date: As soon as possible
Duration of employment: Initial contract for 2 years
Working time: 39 hours per week
Salary: E13 TV枚D Bund
Place of work: Braunschweig
Probation period: 6 months
Closing date: 10.08.2025
The departments 鈥楥hemical Biology鈥�, led by Prof. Mark Br枚nstrup and 鈥楻NA Biology of Bacterial Infections鈥� led by Prof. J枚rg Vogel, at the Helmholtz Centre for Infection Research (HZI), are offering a position for a
Postdoctoral Researcher in 鈥極rganic Chemistry and Chemical Biology鈥� (f/m/d)
As a member of the Helmholtz Association, the Helmholtz Centre for Infection Research, based in Braunschweig, conducts top-level research in the field of infectious diseases. Our scientists develop novel methods and strategies to fight infectious diseases faster and more effectively. Our common goal is to develop novel approaches for the prevention, diagnosis and treatment of infectious diseases. Our research focuses on bacterial and viral pathogens, their interaction with the human immune system and new effective substances and vaccines.
The aim of the department 鈥楥hemical Biology鈥� is to discover and characterize novel anti-infectives through screening, mode of action studies and chemical synthesis. The department 鈥楻NA Biology of Bacterial Infections鈥� explores the RNA biology of bacterial pathogens, members of the human microbiome, as well as phages. Their main focus is now shifting to the development of programmable RNA antibiotics, also called asobiotics.
Responsibilities:
The successful candidate will be responsible for the design and synthesis of novel RNA-binding drug conjugates. Such compounds should serve as next-generation precision drugs to selectively block targets in single bacterial species. The project will be conducted in close collaboration with two HZI departments, located in Braunschweig and W眉rzburg, and will involve the multistep synthesis of peptide-like molecules coupled to delivery units. The incumbent will get profound exposure to chemistry as well as infection biology.Requirements:
Candidates should have a completed Ph.D. degree in organic chemistry, medicinal chemistry or related areas as proven by high quality scientific publications. Candidates should be highly motivated and be able to design and conduct multistep synthesis. Profound knowledge in organic chemistry, purification and analytical tools such as HPLC/MS and NMR spectroscopy are mandatory. Interested applicants should have an overview knowledge on drug research. The ability to work in a multidisciplinary and international team is mandatory; it will involve regular business trips to W眉rzburg. Recommended knowledge of written and spoken German and English.Advantageous for this position:
- Experience in peptide chemistry, conjugation chemistry and microbiological compound profiling
- First experiences in grant writing
We offer you:
- An attractive and varied job in a future-oriented research institute with an international environment at the Science Campus South in Braunschweig
- A state-of-the-art infrastructure and the latest technologies
- Flexible working hours, part-time models as well as home office
- A corporate culture of appreciation and promotion of equal opportunities
- Extensive training and continuing education opportunities to develop professional knowledge and personal skills
- A family office to support family and career as well as childcare offers
- Interesting additional public service benefits
- Possible subsidy of the job-ticket
People with severe disabilities and equivalent professional qualifications who are suitable for the position are given preference. In order to protect your rights, we ask you to provide us with a clearly recognizable reference to the existence of a degree of severe disability in your cover letter or resume.
The HZI is actively committed to equality, diversity and integration. For this reason, the HZI pursues the goal of professional equality between women and men. The position is suitable for part-time work.
How to apply:
When sending us your application documents, please confirm that you have read our privacy policy and that you agree to the processing of your personal data. Please use the text module in our for this purpose. Without these declarations we cannot consider or process your application and will immediately delete any application documents already received after the application deadline.
Please include a cover letter, resume, (employment) references, certificates, and (if available) work samples or reference projects with your application materials. Please refrain from sending a photo.
For further information, please contact Prof. Mark Br枚nstrup, phone: 0531 6181-3400, e-mail: mark.broenstrup@helmholtz-hzi.de
Please send your complete application, quoting the reference number 064/2025, to the Helmholtz Centre for Infection Research GmbH, Human Resources Department, Inhoffenstr. 7, 38124 Braunschweig, Germany or by e-mail. If you send your application in electronic form, please provide a summary in one single (1) pdf document.
We look forward to receiving your application!
Get in touch
JobsHZI@helmholtz-hzi.de
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About the employer
Helmholtz-Gemeinschaft
Arbeiten bei Helmholtz - Spitzenforschung als Beitrag zu Wachstum und Wohlstand
Aus dem 1958 gegr眉ndeten "Arbeitsausschuss f眉r Verwaltungs- und Betriebsfragen der deutschen Reaktorstationen" entwickelten sich innerhalb von 40 Jahren die lose verbundenen Forschungszentren der Helmholtz-Gemeinschaft. Namensgeber f眉r die Gemeinschaft war einer der gr枚脽ten Naturwissenschaftler des 19. Jahrhunderts: Hermann von Helmholtz. Als einer der letzten Universalgelehrten verstand es Helmholtz, naturwissenschaftliche Forschung in die technologische Praxis zu f眉hren und so Br眉cken zwischen den Forschungsfeldern Medizin, Physik und Chemie zu schlagen.聽
Als gr枚脽te Wissenschaftsorganisation Deutschlands besch盲ftigt die Helmholtz-Gemeinschaft in ihren 18 naturwissenschaftlich-technischen und biologisch-medizinischen Forschungszentren mehr als 33.000 Mitarbeiter. In den sechs Forschungsbereichen Energie, Erde und Umwelt, Gesundheit, Schl眉sseltechnologien, Struktur der Materie sowie Luftfahrt, Raumfahrt und Verkehr kooperieren die Helmholtz-Wissenschaftler im Sinne der Nachhaltigkeit untereinander und mit externen Partnern. Ziel der Arbeit der Helmholtz-Gemeinschaft ist die Schaffung tragf盲higer Grundlagen f眉r die Gestaltung der Zukunft.聽
Um sich auch zuk眉nftig den aktuellen wissenschaftlichen Fragestellungen widmen zu k枚nnen, hat die Nachwuchsf枚rderung bei Helmholtz oberste Priorit盲t. Unter dem Prinzip der Chancengleichheit bietet Helmholtz Jobs und Stellenangebote f眉r hochqualifizierte Nachwuchskr盲fte auf allen Ebenen. Auch nach dem Berufseinstieg bei Helmholtz werden die Mitarbeiter umfangreich gef枚rdert und im Sinne des Talentmanagements der Gemeinschaft gef枚rdert. Zudem gibt es mit den Graduiertenschulen und Kollegs spezielle Angebote zur F枚rderung und Weiterentwicklung der Potenziale von Doktoranden und Postdocs.聽
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